Secrete cytokines such as TGF-β and IL-10 which suppress cytotoxic CD8+ T cells and stimulate Tregs. Promote tumor cell proliferation, angiogenesis, and tissue remodeling through production of growth factors and chemokines such as EGF, FGF, VEGF, and TGF-β. (22,23). This evidence concerns the gene CD8A and neoplasm.