Compared to people free of CIND at baseline, those with CIND had lower levels of CR proxies and composite CR score, and were older, more likely to be female, to smoke, and to have hypertension, diabetes, ischemic heart disease, and heart failure, and to carry the APOE‐ε4 allele, while less likely to have a heavy alcohol consumption (P < 0.02, Table 1). Here, APOE is linked to Hypertension.