TARDBP and Alzheimer disease: TAR DNA/RNA binding protein 43 (TDP‐43) was the first identified protein in the postmortem spinal cord and cortex samples from amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) patients [1], then later found in the brains of patients with other neurodegenerative diseases, including Alzheimer's disease (AD), lewy body diseases, and Huntington's disease (HD) [2, 3, 4].