Such as in the anterior horn region of the spinal cord in sporadic ALS cases [35], the ALS‐related FOSMN syndrome patients brain [36], the deep cortical white matter region of FTLD‐TDP brain [25], and even the oligodendrocytes of AD and Lewy body dementia [37], the cytoplasmic TDP‐43 accumulation could be detected. This evidence concerns the gene TARDBP and Lewy body dementia.