Actually, in terms of TDP‐43 associated diseases, the oligodendrocyte morphological defects can be seen and accompanied by abnormal myelin sheath structure and large number of inclusions in ALS patients [23, 24, 25, 26, 27], and even the damaged myelin structures were found in the differentiated NG2+ precursor cells [23]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.