As the mis‐localization of TDP‐43 in cytoplasm can lead to the nuclear depletion of TDP‐43 in ALS and FTLD [1, 28, 51], as well as other neurological disorders [19, 20, 21, 22, 49], the combination of cytoplasmic inclusions has been thought to critically contribute to TDP‐43's neuropathology [52]. Here, TARDBP is linked to nervous system disorder.