TEM revealed a significant reduction in the number of mitochondria, irregularly shaped nuclei, and uneven chromatin distribution in tumor cells in the sh-PRR34-AS1 group, which were greater in the sh-PRR34-AS1+miR-498 antagomir and sh-PRR34-AS1-ov-MIEF2 groups (Figure 7F). Here, PTGDR is linked to neoplasm.