However, other factors such as age, serum PSA levels, risk stratification for recurrence, prognostic grouping, lymph node metastasis, expression levels of CD8 and PD-1, and the combined expression of IL-38 with CD8 or PD-1 did not exhibit statistical significance in predicting the survival rates of prostate cancer patients. Here, KLK3 is linked to Familial prostate cancer.