CD274 and acute myeloid leukemia: To evaluate whether PAI-I also induces PD-L1 in human tumor cells, PAI-1-overexpressing (PAI-1 OE) HEK293T (fetal renal cells), ES2 (ovarian clear-cell adenocarcinoma cells), MOLM14 (acute myelogenous leukemia cells), and K562 (chronic myelogenous leukemia cells) cells were generated.