We then examined Ig isotypes (IgM, IgG1-4 and IgA1, 2) elicited against SARS-CoV-2 spike (Figure 2) and RBD (Supplementary Figure S2) in sera from the 12 vaccinated subjects as compared to four samples from non-vaccinated COVID-19-negative controls. The gene discussed is IGHA1; the disease is COVID-19.