SIGLEC1 and acute myeloid leukemia: To elucidate the potential role of nonmalignant macrophages derived from bone marrow in promoting chemotherapy resistance in AML blasts, researchers have discovered that the majority of granulocytes (CD11b+F4/80-Ly6G+) and monocytes (CD11b+F4/80+CD169-) were eliminated following treatment with cytarabine and doxorubicin (60).