By analyzing various genes associated with the M1/M2 phenotype, including iNOS, TNF-α, CXCL10, CXCL9, TGF-β1, IL-12β and IL-6, researchers found that spleen LAMs exhibited more M2 characteristics in T-ALL and AML mice, whereas bone marrow LAMs displayed more M1 features. This evidence concerns the gene IL6 and acute myeloid leukemia.