Some of them are neurodegenerative diseases, e.g., Parkinson’s disease (PD), AD and prion disease, e.g., Creutzfeldt-Jakob disease (CJD), fatal familial insomnia (FFI) thus the concept that tumors are prion like disease is reflected: S100A9, p53, Beta-2-microglobulin (B2M) amyloids are involved in numerous tumors (Li et al., 2022). This evidence concerns the gene B2M and neurodegenerative disease.