In addition, other studied metabolic factors such as tyrosine, type 2 diabetes, valine, HbA1c, histidine, fasting glucose, leucine, TC, sphingomyelins, lactate, phenylalanine, apolipoprotein A-I, apolipoprotein B, 3-hydroxybutyrate, HbA1c, alanine, albumin, acetate, citrate, creatinine, fasting insulin, glucose, glutamine, pyruvate, sphingomyelins, total cholesterol, and triglycerides didn’t exhibit significant causal associations with PCOS. Here, INS is linked to type 2 diabetes mellitus.