NEFL and Alzheimer disease: In parallel, recent advancements in diagnosing Alzheimer's disease have turned towards using several accessible blood tests that measure biomarkers such as amyloid-β and tau pathology, both recognized features of the disease, in addition to assessing neurodegeneration [97, 107] In a retrospective study conducted by Benedet et al. [98], an interesting correlation between plasma NfL levels and magnetic resonance imaging measurements of gray and white matter levels in the Alzheimer's Disease Neuroimaging Initiative was explored.