Suppressing miR-34a in AECs was shown to inhibit bleomycin-induced p53 and prevent PF, whereas upregulating miR-34a increased p53 and apoptosis in AECs of mice unexposed to bleomycin.[40] In our study, we also observed significantly decreased expression of SIRT1 mRNA in the PBMCs from PM/DM group compared with HCs. The gene discussed is TP53; the disease is pemphigus foliaceus.