Spt4 could aid RNA polymerase II activity by reducing the dissociation of polymerase from the template.[88,89,90] Inhibition of Spt4 and Supt4h expression was reported to successfully reduce mHTT level selectively and limit its aggregation and toxicity with no significant effect on the overall mRNA synthesis, [87] providing a novel target of disease-modifying therapies for HD. The gene discussed is SUPT4H1; the disease is Huntington disease.