PSA is prostate specific antigen and elevated levels of PSA could be caused by conditions that lead to disruption of the epithelial cells of the prostate basal membrane, such as prostatitis, benign prostatic enlargement (BPE), prostate biopsies and surgery or decreased by medication, including 5-alpha reductase inhibitors (48–51). The gene discussed is KLK3; the disease is urogenital neoplasm.