Similarly, an earlier study suggested that elevated expression of histamine receptor H1 in HCC cells increased HCC cell growth and metastasis, whereas inactivation of histamine receptor H1 by terfenadine inhibited HCC tumor growth and metastasis.25 Interestingly, our data further showed that clemastine induced CAT, SOD1, and TNFa expression at 37°C. Here, HRH1 is linked to hepatocellular carcinoma.