Furthermore, the KRT81 + malignant cluster emerged as a predictor for various cancers, including sarcoma (SARC), acute myeloid leukemia (LAML), mesothelioma (MESO), ovarian cancer (OV), cervical cancer (CESC), prostate cancer (PRAD), and lung adenocarcinoma (LUAD).41,42 These findings suggested that KRT81 may serve as a pan-cancer prognostic marker. Here, KRT81 is linked to cervical squamous cell carcinoma.