INS and Insulin resistance: Another and very original study by La Vignera et al. explored the effects of a 12-week VLCKD on body weight, indices of β-cell dysfunction, insulin resistance, and serum levels of Total Testosterone (TT) in overweight or obese male patients with metabolic hypogonadism, showing that VLCKD could be used to improve β-cell secretory function and insulin sensitivity [77].