In addition to mucins, the expression of cytokines (including IL2, IL10, IL15, IFNG, TNF, TNFRSF1A, TNFRSF1B, IL6, IL1A, IL1B, IL1R1, IL1R2, IGFB1, TGFBR1, and TGFBR2) and chemokine receptors (CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CXCL8, CXCR1, CXCR2, CXCR4, CSF1, and CSF1R) in each cell cluster was also detected (Figure S4C, D) since they are essential factors of the tumour microenvironment and are closely correlated with tumorigenesis.22 This evidence concerns the gene IL1R2 and neoplasm.