To highlight the dynamics of communication across cell clusters, interactions among the immune module (including naïve B cells, NK cells, CD4+ T cells, CD8+ T cells, and plasma cell populations), tumour module (including stem‐like epithelial cells, epithelial cell subset 1, and subset 2), fibroblast module (including crypt‐top fibroblasts, myofibroblasts, and inflammatory fibroblasts), myeloid module (including myeloid cells), and endothelial module (including endothelial cells) were detected. This evidence concerns the gene CD4 and neoplasm.