It is well known that the mucin protein family is highly expressed in mucinous colorectal adenocarcinoma,2 so the expression of secreted mucins (including MUC5AC, MUC5B, MUC6) and transmembrane mucins (including MUC1, MUC3A, MUC4, MUC12, MUC13, MUC15, MUC16, MUC17, MUC20) was detected in each cell cluster. The gene discussed is MUC15; the disease is colorectal mucinous adenocarcinoma.