Furthermore, AGE supplementation in Diabetic animals was found to cause a significant decline in the expression of NF-κB and TLR-4 levels compared to levels observed in the DM control group (Fig. 9A), and NF-κβ/TLR-4 expression and SERCA/Ca2+ pathways were evaluated under physiological and pathological diabetic conditions. This evidence concerns the gene TLR4 and diabetes mellitus.