Expression of luciferase (Fig. 1G), as well as endogenous IFIT-2 (Fig. 1H) and CXCL-10 (Fig. 1I) was significantly reduced following ruxolitinib treatment of Gag-LUC-infected cells indicating that infection with this Gag-LUC fusion virus induces type I IFN production, to induce endogenous ISG and IFN reporter expression. The gene discussed is IFNA1; the disease is infection.