As in THP-1 cells, infection of MDM with Gag-LUC induced a robust type I IFN response leading to significantly higher expression of CXCL-10 (Fig. 2A), IFIT-2 (Fig. 2B) and MxA (Fig. 2C), as well as CXCL-10 protein (Fig. 2D) compared to VSV-G pseudotyped LAI infection, all of which was reduced by ruxolitinib treatment. Here, IFIT2 is linked to infection.