CGAS and viral infectious disease: Finally luciferase reporter activity in Gag-LUC infected THP-1 Dual cells was significantly reduced in the presence of STING inhibitor H151 [38] and cGAS inhibitor RU.521 [39] (Fig. 4G, Suppl Fig. 4E), confirming cGAS/STING-dependent sensing of viral reverse transcripts during Gag-fusion virus infection.