New phenotypes were added for a total of five genes: BRAF with sporadic AVM (strong evidence) and LM (moderate evidence), GNA11 with Sturge-Weber syndrome (strong evidence), MAP2K1 with epithelioid haemangioma (strong evidence), MAP3K3 with cerebral cavernous malformation (definitive evidence) and PIK3CA with generalised lymphatic anomaly (strong evidence). This evidence concerns the gene GNA11 and famililal cerebral cavernous malformations.