MAP2K1 and cerebral cavernous malformation: New phenotypes were added for a total of five genes: BRAF with sporadic AVM (strong evidence) and LM (moderate evidence), GNA11 with Sturge-Weber syndrome (strong evidence), MAP2K1 with epithelioid haemangioma (strong evidence), MAP3K3 with cerebral cavernous malformation (definitive evidence) and PIK3CA with generalised lymphatic anomaly (strong evidence).