Latent membrane protein 1 (LMP1) can increase the expression of VEGF through the JNKs/c-Jun signaling pathway, and LMP1-targeted DNAzyme (DZ1) can enhance the radiosensitivity of nasopharyngeal carcinoma (NPC) cells by inhibiting the activity of HIF-1/VEGF [162]. The gene discussed is HIF1A; the disease is nasopharyngeal carcinoma.