Depression had positive correlations with number of siblings (r = 0.29, p < 0.01) and ACE (r = 0.30, p < 0.01), and negative correlations with age (r = -0.19, p < 0.01), education (r = -0.33, p < 0.01), being married (r = -0.30, p < 0.01), and family income (r = -0.15, p < 0.01). The gene discussed is ACE; the disease is major depressive disorder.