IGFBP2 and posterior cortical atrophy: We have preliminarily confirmed that ICA-CUR hinders the development of PCa by affecting the gut microbiota-SCFAs-IGFBP2 axis, but we have not conducted long-term studies on the effects of ICA-CUR on gut microbiota, and the optimal treatment duration with ICA-CUR for PCa still needs further clarification.