Specifically, we identified LOX-1, VEGF-A, OPG, ADM, and MMP-10 as potential causal risk factors for CRC, while PTX3, TNF-R2, and MMP-7 may be protective, VEGF R1 as a potential drug target based on results from Mendelian randomization analyses. This evidence concerns the gene TNFRSF11B and colorectal carcinoma.