When pan-pQTLs were used as instrumental variables, ADM (OR = 1.38 (1.08–1.77), P = 9.1e-2) and MMP-10 (OR = 1.19 (1.00-1.43), P = 0.04) were found to increase the risk of CRC. This evidence concerns the gene MMP10 and colorectal carcinoma.