Then the transcriptomic and clinical data of patients in the TCGA database were analyzed, and six DNA hypermethylation-regulated genes (PDE7B, RORA, OBSCN, APCDD1, SLC22A1, and PNPLA7) with different degrees of underexpression were found to be significantly underexpressed in HCC. This evidence concerns the gene PDE7B and hepatocellular carcinoma.