Furthermore, zinc finger proteins such as the transcription factor Snail can promote the EMT process by inhibiting the transcription of epithelial markers such as E-cadherin and upregulating the expression of mesenchymal cell markers such as Vimentin. And a large number of studies have shown that the EMT process in hepatocellular carcinoma is associated with the invasive metastatic ability of hepatocellular carcinoma cells [22, 23]. The gene discussed is ZNF146; the disease is hepatocellular carcinoma.