COX10 and ischemia: This mechanism ultimately contributes to the myocardial protective effects of MTH, which is consistent with the findings presented in Sects. "MTH reduced myocardial infarction area and improved hemodynamic performance after ischemia–reperfusion injury in rats" to "MTH upregulates the level of O-GlcNAcylation-modified COX10 and promotes its transfer to mitochondria".