Multiple studies have demonstrated that older age [19, 42, 44, 67, 68], lower lymphocyte count [19, 44, 67, 69] ow serum albumin levels [19, 69], longer dialysis vintage [69] use of corticosteroids/ immunosuppressive drugs [69, 70] lower vitamin-D levels, diabetes and history of cancer [44] are associated with poor antibody response while previous SARS CoV-2 infection [40, 68, 69] longer interval between vaccine doses [68], female gender [40] dialysis adequacy [55] were found to be associated with stronger antibody response. The gene discussed is ALB; the disease is cancer.