Eoxsome miR-25-3p promoted colorectal cancer development by inducing vascular permeability and angiogenesis [62].MiR-590-5p was upregulated in the CRC tissues compared with normal tissues, which inhibited CRC angiogenesis mainly by affecting NR-90/VEGF-A, reducing the enhanced migration ability of cancer cells [63]. The gene discussed is VEGFA; the disease is colorectal cancer.