Fecal occult blood test is more affordable, less invasive, cost-effective, and more specificity for advanced CRC, but its sensitivity is limited both for early and advanced CRC [5, 6].Although endoscopy has a higher sensitivity and specificity for CRC diagnosis, it is expensive, time-consuming, and invasive, which also increases the psychological and social burden on patients [7].Carcinoembryonic antigen (CEA) is another noninvasive method for diagnosing CRC, but it has lower sensitivity and is always significantly elevated in benign diseases [8]. This evidence concerns the gene CEACAM5 and colorectal carcinoma.