EpCAM, CD63, CD9, and CD147 were repeatedly recognized as positive protein in EVs in CRC, the 4proteins were all tetraspanins (also termed 4-transmembrane cross-linked proteins) and were indicated to facilitate the entry of specific cargos into EVs [75].Thus, these 4 proteins could be used as a biomarker panel, which was also specificity for CRC, to improve the diagnostic efficiency for CRC. Here, CD9 is linked to colorectal carcinoma.