SHANK3 and neurodegenerative disease: Similarly, several genes implicated in other neurogenerative diseases and neuropsychiatric disorders expressed multiple isoforms in human frontal cortex, including SOD1 (amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD); Fig. 5i) with two isoforms expressed with a median CPM > 1, SNCA (Parkinson’s disease (PD); Fig. 5i) with four, TARDBP (TDP-43 protein; involved in several neurodegenerative diseases; Fig. 5i,j) with four and SHANK3 (autism spectrum disorder; Fig. 5k,l) with three.