Other notable genes with new high-confidence isoforms include MTHFS (25%; major depression, schizophrenia and bipolar disorder48), CPLX2 (10%; schizophrenia, epilepsy and synaptic vesicle pathways49) and MAOB (9%; currently targeted for Parkinson’s disease treatment50; Fig. 3c). Here, MTHFS is linked to epilepsy.