The TNFSF12-219 isoform was upregulated in cases with AD whereas TNFSF12-203 was upregulated in controls (Fig. 6c–e), even though the TNFSF12 gene was not differentially expressed when collapsing all transcripts into a single gene measurement (Fig. 6c). This evidence concerns the gene TNFSF12 and Alzheimer disease.