FGF20 and Cerebral cortical atrophy: The repetitive US stimulation reduces cortical atrophy in humans (in AD disease)36, which is similar to our result in mice, the strongly upregulated FGF20 effects is mediated by FGFR1 receptor, which receptor has the strongest expression in the hippocampus; enhancing our results the rs12720208 SNP variant carrier humans have significantly increased gray matter volume than the other genetic variation of FGF20, indicating the neurotrophic activity of FGF20 on neurons, on the other hand the FGF20 through MAPK and PI3K/AKT signaling cascades, mediating neuroprotective effects in vitro37,38.