Most of the LEGs, including BUB1B, CDK7, CENPF, FOXM1, KIF11, ORC6, PBK, RAD51, TTK, CCNE2, and MYC, have previously been reported to be associated with prostate cancer, particularly in the context of metastasis, and other LEGs, including ECT2, GINS2, PARD6A, RAD51AP1, RFC3, RFC4, and TUBB4B, have also been reported to function in other cancer occurrences. Here, RFC4 is linked to Familial prostate cancer.