The analysis of prostate cancer SNV data indicates that (Fig. 1D), in high mutation samples (TP53 + SPOP + TTN), samples with TP53 mutations are significantly enriched in those with Gleason grade 5 (8.28e-03) and in samples with extraprostatic extension of prostate cancer (1.756173e-34). The gene discussed is SPOP; the disease is prostate carcinoma.