Then, we analyzed the 19 LEGs (BUB1B, CCNE2, CDK7, CENPF, ECT2, FOXM1, GINS2, KIF11, MYC, ORC6, PARD6A, PBK, RAD51, RAD51AP1, RFC3, RFC4, RPL12, TTK, and TUBB4B) which drive the prostate cancer lineage plasticity through the RTK/RAS signaling pathway as identified using GSEA. This evidence concerns the gene CDK7 and Familial prostate cancer.