Then, we analyzed the 19 LEGs (BUB1B, CCNE2, CDK7, CENPF, ECT2, FOXM1, GINS2, KIF11, MYC, ORC6, PARD6A, PBK, RAD51, RAD51AP1, RFC3, RFC4, RPL12, TTK, and TUBB4B) which drive the prostate cancer lineage plasticity through the RTK/RAS signaling pathway as identified using GSEA. The gene discussed is KIF11; the disease is prostate carcinoma.