CENPF and FOXM1 drives the malignancy of prostate cancer101, CDK7 is a crucial gene in castration-resistant prostate cancer cells70, KIF11 is an indicator of the invasiveness of prostate cancer73,74, RAD51 is overexpressed in invasive prostate cancer77, and MYC can promotes prostate cancer development80. This evidence concerns the gene CENPF and Familial prostate cancer.