Secondary loci found on chr9:22381987-23201516 and chr21:31405230-33951574 comprise many potential cancer genes, but two, Erb-B2 receptor tyrosine kinase 2 (ERBB2) and WEE1 G2 checkpoint kinase (WEE1), stand out as likely candidates for disease risk, as both are frequently mutated, amplified or dysregulated in human bladder tumors. The gene discussed is WEE1; the disease is urinary bladder neoplasm.