ERBB2 and neoplasm: Specifically, after applying multiple variant effect predicting programs, the ERBB2 gene had two putatively damaging missense variants, chr9:22775561 C > A and chr9:22775767 C > G, each found in two tumor alignments, which create the D277Y and D251H protein changes in ERBB2. There was also a single putatively damaging C > G variant in the WEE1 gene at chr21:32843843, leading to a predicted P175R protein change (Supplementary Table 5).