CAPRIN1 and gastric cancer: In gastric cancer cells, a complex containing overexpressed circIPO7 blocks the caprin-1-G3BP1 interaction, dissociating caprin-1 and its target mRNAs (EGFR and mTOR) from the ribosome, leading to inhibition of their translation and consequent inactivation of the PI3K/AKT/mTOR pathway [13].