Eighteen additional rare NOTCH1 VUS (including one variant found in two reportedly unrelated families) were identified by screening of the CGC database but excluded from this analysis due to insufficient evidence of pathogenicity (e.g., relatively high allele counts in gnomAD, low in silico pathogenicity predictions, lack of segregation, poor phenotypic fit, and/or alternative molecular diagnoses to explain the proband’s CHD) (Supplementary Table 3). Here, NOTCH1 is linked to coronary artery disorder.