This study had a higher proportion of mechanically ventilated patients and may have been underpowered to detect significant differences in delirium/coma due a smaller cohort (n = 26–42/group) than our study and did not adjust for covariates known to affect delirium/coma risk including baseline differences in CRP, benzodiazepine, opiate, or dexmedetomidine use47. The gene discussed is CRP; the disease is delirium.