Both of these models exhibit muscular dystrophy and heart disease; however, whereas the Lmna N195K mice have an early disease onset and die around 10–14 weeks of age [8], the Lmna H222P mice do not display a phenotype until around 12 (males) or 24 (females) weeks and die around 28 (males) and 40 (females) weeks of age [35]. Here, LMNA is linked to muscular dystrophy.