Mutations in the LMNA gene, which encodes the nuclear envelope proteins lamin A and C, cause a plethora of human diseases (‘laminopathies’) that include dilated cardiomyopathy, Emery-Dreifuss muscular dystrophy, LMNA-related congenital muscular dystrophy (L-CMD), and Hutchinson-Gilford progeria syndrome [1–5]. Here, PROS1 is linked to congenital muscular dystrophy due to LMNA mutation.