It has been reported that the expression levels of NRF2 and SLC7A11 are upregulated in esophageal squamous cell carcinoma tissues; NRF2 is associated with metastasis, TNM stage, and lymph node metastasis in patients with esophageal squamous cell carcinoma, and NRF2 overexpression leads to radioresistance development [82]. This evidence concerns the gene NFE2L2 and esophageal squamous cell carcinoma.