Conche et al. have reported that GPX4 deficient hepatocellular cells promote the immunosuppressive tumor microenvironment, which is characterized by the infiltration of CXCL10-related cytotoxic CD8+ T cells, tumoral PD-L1 upregulation, and HMGB1-mediated myeloid-derived suppressor cell (MDSC) infiltration; PD-1 blockade substantially increases the survival of GPX4 deficient animal models [130]. The gene discussed is CD8A; the disease is neoplasm.