MALAT1, HOTAIR, and H19 lncRNAs affect tumor growth and proliferation by interacting with various microRNAs and transcription factors to regulate cell cycle progression and ki67 level in a way that down-regulation of these lncRNAs is associated with decreased ki67 level, increased p21 expression, G1 cell cycle arrest, and therefore, suppressed proliferation [54–56]. The gene discussed is HOTAIR; the disease is neoplasm.