HOTAIR and neoplasm: Due to the proven effects of tumor suppressor miR-141 and miR-101-3p on down-regulating HOTAIR [49, 50], and since recent articles demonstrated the exosomal transfer of these miRs from MSCs to various cells [51, 52], hypothetically, they could be responsible for the demonstrated down-regulation of HOTAIR in the HL-60 cells treated with BM-MSC exosomes in our study.