We did not find significant difference (p > 0.05) in Klotho serum level between SSc patients after Iloprost infusion, both at t1 (2.5 ± 0.6 pg/ml) and t2 (2.3 ± 0.4 pg/ml), and HC (2.3 ± 0.6 pg/ml). This evidence concerns the gene KL and systemic sclerosis.