IFNA1 and systemic sclerosis: A high frequency of CD123+ and/or BDCA2+ cells, identified as pDCs, as well as an increased IFN response, were detected in skin biopsies of patients suffering from cutaneous lupus erythematous (CLE) [251], systemic sclerosis [252], vitiligo [253], alopecia areata [254], or several other skin disorders [255].