Patients suffering from warts due to Verruca vulgaris infection, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome exhibit reduced blood pDC numbers, loss of IFN-α production by mononuclear cells upon stimulation with HSV-1 or CpG-DNA, lack of pDC infiltration and induction of IFN-induced MXA viral restriction factor [129]. This evidence concerns the gene IFNA2 and infection.