PDC and infection: During systemic MCMV infection, neither Myd88 deficiency nor pDC depletion affected the induction of ISG expression in the spleen, which is consistent with the greater resistance of Myd88-KO mice to infection than of Ifnar1-KO mice, thus indicating that efficient cell-intrinsic antiviral immunity is achieved even in the absence of pDCs or IFNs (Table 3) [82].