Notably, studies have shown that VDR is also associated with various aging-related diseases, such as Alzheimer’s disease, sarcopenia, and skin aging.70–72 Moreover, Keisala et al.73 reported that 6-month-old VDR knockout mice exhibited the features of aging, including a decreased survival rate, early alopecia, epidermal cyst development, and enlarged sebaceous glands. This evidence concerns the gene VDR and early-onset autosomal dominant Alzheimer disease.