Mice deficient in the gene encoding VDR exhibit aging phenotypes,46 and VDR activation by 1,25(OH)2D can increase the level of Klotho, which protects against aging phenotypes such as skin atrophy, osteopenia, and atherosclerosis.47 These findings suggest a potential therapeutic role for VDR in cellular senescence. This evidence concerns the gene VDR and skin atrophy.