TP53 gene mutations occur in 5–10% of all MDS and AML cases [2], including 20–25% of the low-risk MDS with isolated del 5q, where they are often monoallelic [3] and 40–50% of MDS and AML with complex karyotypes, where they are generally biallelic [4]. This evidence concerns the gene TP53 and myelodysplastic syndrome.