As an E3 ubiquitin ligase, TRIM65 promotes the occurrence and development of a variety of tumors by degrading tumor-related proteins, such as ARHGAP35 [20], ANXA2 [21], Axin1 [22], p53 [23], PPM1A [24], etc. However, the research on the function and mechanism of TRIM65 is still in its infancy, and the role of TRIM65 in RCC is never reported. Here, TRIM65 is linked to renal cell carcinoma.