As an E3 ubiquitin ligase, TRIM65 promotes the occurrence and development of a variety of tumors by degrading tumor-related proteins, such as ARHGAP35 [20], ANXA2 [21], Axin1 [22], p53 [23], PPM1A [24], etc. However, the research on the function and mechanism of TRIM65 is still in its infancy, and the role of TRIM65 in RCC is never reported. The gene discussed is TRIM65; the disease is neoplasm.