In contrast to previous studies that focused on SPIN1 promoting tumorigenesis through four tumor-associated signaling pathways (Wnt, PI3K/AKT, RET, and ribosomal subunit protein–MDM2–p53), our research identified a distinct and significant occupancy of SPIN1-WT at genomic regions associated with the MAPK signaling pathway. Here, MDM2 is linked to neoplasm.