SPIN1 exerts its oncogenic function by activating multiple cancer-related signaling pathways, such as the PI3K/AKT, Wnt, uL18–MDM2–p53, and RET signaling pathways (Franz et al., 2015; Chen et al., 2016; Fang et al., 2018; Devi et al., 2019). Here, SPIN1 is linked to cancer.