PHAX::AC007450.2 has not been reported in ALL cases previously; however, PHAX, a protein-coding gene involved in the nuclear export of small nuclear RNA (Ohno et al, 2000), appears in a single PHAX-IGH fusion that was recently reported in a ETV6::RUNX1-like case (Li et al, 2021). The gene discussed is RUNX1; the disease is acute lymphoblastic leukemia.