PRDM9, which shares the SSXRD, SET, and KRAB protein domains with PRDM7, has been implicated in genetic predisposition to pediatric B-ALL (Hussin et al, 2013; Thibault-Sennett et al, 2018), whereas our findings suggest that this association might extend to other members of the PRDM gene family. The gene discussed is SET; the disease is precursor B-cell acute lymphoblastic leukemia.