REH has an abnormally high expression of both CBFA2T3 and RUNX1 (Rouillard et al, 2016), and the RUNX1 fusion activates a topological disruption of multiple genes in this region that promotes BCP-ALL proliferation (Jakobczyk et al, 2021). The gene discussed is RUNX1; the disease is acute lymphoblastic leukemia.