This is because it helped to overcome technological challenges in the field of GPCR research and generated a robust platform for dissecting physiologically relevant CLR interactome at a proteome-wide level not only in HDLEC but also in other primary human cells (including neurons, cardiomyocytes, vascular smooth muscle, and cancer/malignant cells) and tissues, where this GPCR plays important roles (13, 17, 22, 25). This evidence concerns the gene DCLK3 and cancer.