CLR is expressed in VSMC and cardiomyocytes, while its three agonists influence vasodilation, vascular permeability, and cardiac function, and are implicated in the pathophysiology of hypertension, atherosclerosis, ischemia, cardiac hypertrophy, and heart failure (19, 21, 22, 95). This evidence concerns the gene DCLK3 and cardiac hypertrophy.