To further elucidate the relationship between aggresomes and LC3A, independent of LC3B, and to investigate whether the simultaneous activation of LC3A in CCHE-45 cells is cell-line-specific or a general stress response triggered by aggresomes, we subjected SH-SY5Y neuroblastoma cells to serum starvation. The gene discussed is MAP1LC3A; the disease is neuroblastoma.