TGFB1 and pulmonary venoocclusive disease: Although classical PAH is most frequently caused by mutations in the TGFβ/BMP signalling axis [2–5], rare subtypes such as pulmonary veno-occlusive disease (PVOD) and pulmonary capillary haemangiomatosis (PCH) have distinct genetic associations and are refractory to current clinical management [6].