The second is a single intronic risk variant in TNRC18 recently documented as a strong risk factor in IBD (in R11 beta = 0.79, p = 6.5 × 10−142) and other inflammatory diseases such as ankylosing spondylitis, psoriasis, and iridocyclitis,37 but with a significant opposite-direction protective effect in canonical autoimmune diseases such as hypothyroidism, type 1 diabetes, and multiple sclerosis. Here, TNRC18 is linked to inflammatory bowel disease.